Home Members Vincenzo Ronca

Vincenzo Ronca

Assistant Professor

Internal Medicine

Assistent Professor

E-mail

vincenzo.ronca@hunimed.eu

Education

Dec 2020 – Feb 2024 Joint PhD Program in Immunology and Immunotherapy and Translational Medicine, University of Birmingham, and University of Milano-Bicocca, Milan, Italy
Nov 2022 – Oct 2023 master’s degree in “Advanced Hepatology and Transplant Medicine”, University of Milano-Bicocca, University of Padua, Italy
Nov 2015 – Sep 2020 Residency Program in Internal Medicine CCT date 10/11/2020 – 70/70 cum laude
Oct 2008 – Jul 2014 Medical Doctor, summa cum Laude (110/110 cum laude ed encomio della commissione – summa cum laude) University of Pavia, Pavia (Italy).

Academic background

Current role – Assistant Professor in Internal Medicine (tenure track – RTDB)

May 2019 – December 2023 Fellow at Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, and Liver Unit Queen Elizabeth Hospital University of Birmingham, Birmingham (UK)
Sep 2022 – Jan 2023 Visiting Research Fellow Immunology Frontier Research Centre, Osaka University, Japan – Shimon Sakaguchi’s lab
Dec 2016 – May 2019 Clinical and Research Fellow at Division of Gastroenterology and Centre for Autoimmune Liver Diseases at University of Milan-Bicocca School of Medicine, Monza (Italy)
Sept 2014 – Dec 2016 Research Fellow at Centre for Autoimmune Liver Diseases, Humanitas University, Milan, (Italy)

Grant and Awards

AISF 2023 – Young Investigator award for best Oral presentation
EMBO 2021 – short-term fellowship
Juan Rodes EASL Fellowship 2020 – 2021-2023 (3 years grant)
NIHR Academic Clinical Fellowship in Gastroenterology, Liver Unit and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham UK

Membership and leadership roles

ERN Rare liver – Lead of Autoimmune hepatitis special group
International Autoimmune Hepatitis Group – member since 2015
International Primary Sclerosing Cholangitis group – member since 2022
International Primary Biliary Cholangitis Study group (GLOBE) – member since 2018
Associazione italiana studio fegato (AISF) since 2014.
European Association for the Study of the Liver (EASL) since 2015
American Association for the study of liver diseases (AASLD) since 2023
General Medical Council, Specialist Register since March 2019 (number: 7693775)

Dr. Ronca is a hepatologist whose main area of expertise is autoimmune liver diseases and immunotolerance. He has a medical degree from the University of Pavia (Summa cum laude) and a master’s degree in advanced Hepatology and Transplant Medicine.

Dr. Ronca’s research career has been initially focused on risk stratification and epidemiology of biliary diseases and surgical treatment of hepatocellular carcinoma. He moved to the UK in 2019 as a research fellow and was awarded a NIHR academic clinical fellowship to study the role of regulatory T cells (Tregs) in primary biliary cholangitis (PBC).

During his fellowship, he collaborated in the design and execution of a cell-therapy-based clinical trial using autologous Tregs in PBC (trial currently ongoing). His doctoral studies were conducted at the University of Birmingham, funded by a Juan Rodes Fellowship from the European Association for the Study of the Liver. The focus of his research was a) the crosstalk between biliary epithelium and T cells and b) immunotolerance with a strong focus on regulatory T cell biology. He described a new cell-in-cell structure and mechanism of damage of biliary epithelium, whereby a population of E-cadherin-expressing CD8+ T cells invade the cytoplasm of biliary epithelial cells.

In 2021, he joined the Shimon Sakaguchi Lab at Osaka University (Japan) after being awarded an EMBO fellowship, aiming to develop new strategies to produce antigen-specific induced and stable Treg cells as a therapeutic tool for autoimmune diseases.

In December 2023, Dr. Ronca moved back to Italy to join Humanitas University as Assistant Professor (RTDB) in Internal Medicine and consultant hepatologist. He joined the hepatobiliary immunopathology laboratory directed by Prof. Ana Lleo and the Internal Medicine Unit. His current work is focused on the clinical and pathogenetic aspects of autoimmune liver diseases.

Main research fields:

Liver immunology
Autoimmune liver diseases
Immunotolerance and T-cell biology
Cholestasis and bile acids

Montano-Loza AJ, Ronca V, et al. Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation. J Hepatol. 2022 Jul;77(1):84-97. doi: 10.1016/j.jhep.2022.01.022. Epub 2022 Feb 8. PMID: 35143897.
Davies, S.P*., Ronca, V*., Wootton, G.E. et al. Expression of E-cadherin by CD8+ T cells promote their invasion into biliary epithelial cells. Nat Commun 15, 853 (2024). https://doi.org/10.1038/s41467- 024-44910-2+ T cells promote their invasion into biliary epithelial cells. Nat Comm Nov 2023.
Ronca V, Barabino M, Santambrogio R, Opocher E, Hodson J, Bertolini E, Birocchi S, Piccolo G, Battezzati P, Cattaneo M, Podda GM. Impact of Platelet Count on Perioperative Bleeding in Patients with Cirrhosis Undergoing Surgical Treatments of Liver Cancer. Hepatol Commun. 2022 Feb;6(2):423- 434. doi: 10.1002/hep4.1806. Epub 2021 Oct 30. PMID: 34716696; PMCID: PMC8793986.
Ronca V, Wootton G, Milani C, Cain O. The Immunological Basis of Liver Allograft Rejection. Front Immunol. 2020 Sep 2; 11:2155. doi: 10.3389/fimmu.2020.02155. PMID: 32983177; PMCID: PMC7492390.
Ronca V, Chen QB, Lygoura V, Ben-Mustapha I, Shums Z, Trifa M, Carbone M, Mancuso C, Milani C, Bernuzzi F, Ma X, Agrebi N, Norman GL, Chang C, Gershwin ME, Barbouche MR, Invernizzi P. Autoantibodies in patients with interleukin 12 receptor beta 1 deficiency. J Dig Dis. 2019 Jul;20(7):363- 370. doi: 10.1111/1751-2980.12790. Epub 2019 Jul 10. PMID: 31111679.