Home Members Silvia Giugliano

Silvia Giugliano

Assistant Professor

Food and dietetic sciences

Assistant Professor

E-mail

silvia.giugliano@hunimed.eu
Sito

www.hunimed.eu/faculty/

Academic background

Researcher and Nutritionist, enrolled in the Register of Biologists, section A. She graduated in Biological Sciences at the University of Roma Tre, and then embarked on the research sector by carrying out a PhD in Immunology at the University of Duisburg- Essen, Germany. Following this experience, she then decided to deal with an even more complex and stimulating reality by starting a university career in Denver Colorado, USA. Finally, to convey the wealth of knowledge and experience gathered over the years in her native country, in 2016 she moved to Milan and now works at the Mucosal Immunology and Microbiota Unit at Humanitas University. During this last period, in addition to successfully carrying out research in the immunological, microbiological and metabolic fields, she attended the II Degree Master in Nutrition and Applied Dietetics at the Bicocca University of Milan. At the moment she is PI of a project funded by the PNRR, focused on the identification of multiomic biomarkers for the early prediction of preeclampsia. Furthermore, she is the coordinator of many clinical studies aimed at the characterization of couple infertility and irritable bowel syndrome.

Education

1998-2006 Master Degree in Biological Sciences, 110/110, University of Studi Roma Tre, Rome, Italy
2007-2011 PhD in Immunology, University of Duisburg-Essen, Essen, Germany
2017-2019 II Degree Master in Nutrition and Applied Dietetics, University of Milano Bicocca, Milan, Italy

Academic honors, awards and prices

PNRR – Missione 4 “Istruzione e Ricerca” – Componente 2 “Dalla Ricerca all’Impresa” – Investimento 1.2 “Finanziamento di progetti presentati da giovani ricercatori”, Giugliano Silvia (PI) 20/12/2022-19/12/2025: PREcision MEdicin in Pregnancy: development of a novel Multiomic approach for early prediction of preeclampsia via artificial intelligence tools.
FERRING COVID-19 Investigational Grant in Reproductive Medicine and Maternal Health 2020 RMHH 2020, Giugliano Silvia (PI) 15/11/2020-15/11/2021: Effect of Cryopreservation on SARS-CoV2 Semen Samples: Influence of Two Different Cryopreservation Procedures Evaluated after Thawing.
Marie Curie Individual Fellowship 2017, Horizon2020, Giugliano Silvia (PI) 07/16/19-07/15/21 Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and Offspring’s Immune Development.
2017 Fondazione Umberto Veronesi Postdoctoral Fellowship (FUV), Fondazione Umberto Veronesi, Giugliano Silvia (PI) 12/01/17-01/30/18: The Role of Maternal Microbiota and Microchimerism in Immune Fitness of the New-born.
AGA Research Scholar Award 2016 (AGA), Giugliano Silvia (PI) 07/01/16-06/30/19 Defining Novel Roles of LSECs in the liver microenvironment.
M-14-41, Colorado Clinical & Translational Sciences Institute (CCTSI), Giugliano Silvia (PI) 04/17/15- 04/16/16: Human Trophoblasts: Active Immunological Barrier that Prevents Transmission of Hepatitis C virus at the Maternal-Fetal interface.

Her current research studies are divided into 3 main fields:

Identification of predictive multiomic biomarkers for the early detection of preeclampsia (PE). PE is a syndrome that complicates 4-14% of pregnancies and is the leading cause of maternal-fetal morbidity and mortality. To date, the classification of the different clinical phenotypes has not yet been defined in detail, which makes a personalized therapeutic approach difficult. Therefore, we will use artificial intelligence (AI) tools to analyze predictive biomarkers that allow the prevention and early treatment of the disease, reducing the likelihood of complications for maternal and neonatal health.
Characterization of the microbiota and metabolome in patients with irritable bowel disease (IBS) for the development of a personalized nutritional approach. IBS is a chronic intestinal condition whose high incidence (7-15%) and prevalence make it a major health problem. The pathophysiological mechanisms underlying IBS are heterogeneous and not fully understood. We propose to generate an algorithm that will allow us to identify IBS-specific biomarkers. The ultimate aim of the study will be to rebalance host-microbiota interactions through the development of a personalized nutritional approach.
Characterization of the impact that intestinal permeability has on couple fertility. High intestinal permeability increases inflammation through the translocation of bacteria into the bloodstream. This phenomenon induces insulin resistance which alters the production of sex hormones in both men and women. Furthermore, the increase in intestinal permeability may favor bacterial translocation across the blood-testis and blood-follicle barrier contributing to local inflammation. Therefore, we aim to evaluate the impact that the modulation of intestinal permeability can have on couple fertility.

Carloni S, Bertocchi A, Mancinelli S, Bellini M, Erreni M, Borreca A, Braga D, Giugliano S, Mozzarelli AM, Manganaro D, Fernandez Perez D, Colombo F, Di Sabatino A, Pasini D, Penna G, Matteoli M, Lodato S, Rescigno M. Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science. 2021 Oct 22;374(6566):439-448. doi: 10.1126/science.abc6108. Epub 2021 Oct 21. PubMed PMID: 34672740.
Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Domínguez-Andrés J, Molteni R, Stefanoni D, Cantoni E, Cassina L, Giugliano S, Schraa K, Mills TS, Pietras EM, Eisenmensser EZ, Dagna L, Boletta A, D’Alessandro A, Joosten LAB, Netea MG, Dinarello CA. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021 Apr 6;35(1):108955. doi: 10.1016/j.celrep.2021.108955. PubMed PMID: 33826894.
Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR. Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2015 Oct 15;195(8):3737-47. doi: 10.4049/jimmunol.1500409. Epub 2015 Sep 4. PubMed PMID: 26342030; PubMed Central PMCID: PMC4592818.
Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb;148(2):392-402.e13. doi: 10.1053/j.gastro.2014.10.040. Epub 2014 Nov 4. PubMed PMID: 25447848; PubMed Central PMCID: PMC4765499.
Giugliano S, Oezkan F, Bedrejowski M, Kudla M, Reiser M, Viazov S, Scherbaum N, Roggendorf M, Timm J. Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3. Hepatology. 2009 Sep;50(3):707-16. doi: 10.1002/hep.23096. PubMed PMID: 19637188.