Home Members Mattia Loppini

Mattia Loppini

Associate Professor

Orthopaedics

Associate Professor

E-mail

mattia.loppini@hunimed.it
Sito

www.hunimed.eu/member/mattia-loppini/ ‎

Academic background and education

October 2022 Scientific National Abilitation for Full Professor of Locomotor Apparatus Disease and Physical and Rehabilitative Medicine.
March 2022 – September 2024 Researcher (RTD-B) in Diseases of Locomotor Apparatus Disease and Physical and Rehabilitative Medicine, Humanitas University, Pieve Emanuele (Milan, Italy).
September 2018: Scientific National Abilitation for Associate Professor of Locomotor Apparatus Disease and Physical and Rehabilitative Medicine.
March 2017 – March 2022 Researcher (RTD-A) in Diseases of Locomotor Apparatus Disease and Physical and Rehabilitative Medicine, Humanitas University, Pieve Emanuele (Milan, Italy).
November 2016-September 2017: Advanced Training Course in Clinical Epidemiology, Humanitas University, Rozzano, Milan, Italy.
March 2012-July 2015: Doctor of Philosophy program in Oncology Orthopaedics, Campus Bio-Medico University of Rome, Italy.
May 2010-May 2015: Resident program in Orthopaedic and Trauma Surgery, Vote: 50/50 cum laude, Campus Bio-Medico University of Rome, Italy.
November 2011-August 2012: Clinical and research fellow at Centre of Sports and Exercise Medicine, Barts and the London, Queen Mary University of London, United Kingdom.
July 2008-September 2008: Visiting research fellow at Orthopaedic Surgery Department Ferguson Laboratory for Spine Research, University of Pittsburgh, United States.
September 2003-July 2009: Faculty of Medicine and Surgery, Vote: 110/110 summa cum laude, Campus Bio-Medico University of Rome, Italy.

Academic honors, awards and prices

Principal Investigator, call for proposals PRIN: Research projects of major National Interest –2022, Prot. 2022YME9N3, title “Development and validation of an artificial intelligence algorithm based on clinical and radiographic data for the “virtual follow-up” of patients with total hip arthroplasty”. Funding agency: Italian Ministry of Health.
Institutional Research Grant, 2021, Humanitas Research Hospital. Title: “Conventional versus mobile application-guided follow-up after joint replacement: a randomized controlled study.” Funding agency: IRCCS Humanitas Research Hospital.
Institutional Research Grant, 2020, Italian Ministry of Health. Title: “Preoperative diagnosis of periprosthetic joint infection in patients undergoing total hip and knee arthroplasty revision: development and validation of a machine learning algorithm.” Funding agency: IRCCS Humanitas Research Hospital
Co-Principal Investigator, Young Researcher Change Promoting, Ricerca Finalizzata 2019. Title: “KneE microbiota in the phYsiopathology of oSteoarthritis. Microbes could play an imporTant rOle in a presumed Non-infectious disease (KEYSTONE).” Funding agency: Italian Ministry of Health.
Institutional Research Grant, 2019, Italian Ministry of Health. Title: “Artificial intelligence for the “virtual follow-up” of patients with primary hip and knee arthroplasty: feasibility and efficacy study.” Funding agency: IRCCS Humanitas Research Hospital.
Principal Investigator, Young Researcher Change Promoting, Ricerca Finalizzata 2018. Title: “Identification of early predictors of hip and knee arthroplasty failure by developing an innovative software for the automated analysis of radiographic examinations.” Funding agency: Italian Ministry of Health.
SIOT Level I Research Grant 2017. Title: “Prospective observational study to assess the diagnostic ability of Long-Pentraxin 3 protein for the diagnosis of hip and knee periprosthetic joint infections.” Funding agency: SIOT (Italian Society of Orthopaedic and Traumatology).
SIOT Level I Research Grant 2014. Title: “Role of preoperative pelvic tilt in determining the range of motion and the rate of dislocation after primary total hip replacement.” Funding agency: SIOT (Italian Society of Orthopaedic and Traumatology).

Awards

Visiting Fellowship of European Hip Society for 2018 in The Netherlands.
Best Presentation Award at 13th Congress of European Hip Society, 20-22 September 2018 The Hague, The Netherlands, “PTX3 as a new biomarker for the diagnosis of periprosthetic joint infection: a single-center pilot study”.
Recipient of the 2013 ISAKOS Achilles Orthopaedic Sports Medicine Research Award for the paper “Longo UG, Loppini M, Berton A, Marinozzi A, Maffulli N, Denaro V. The FIFA 11+ program is effective in preventing injuries in elite male basketball players: a cluster randomized controlled trial”.
Recipient of the Certificate Of Excellence in Reviewing 2013 by Foot and Ankle Surgery journal in cooperation with the European Foot and Ankle Society.

1. Clinical and translational research to improve the current techniques and to develop innovative techniques in replacement and arthroscopic hip and knee surgery; to improve the outcome of patients undergoing hip and knee replacement surgery; to develop follow-up protocols based on artificial intelligence for patients with hip and knee replacement; to identify new biomarkers for the diagnosis of periprosthetic infections; to develop new diagnostic tools for periprosthetic infections with the application of machine learning algorithms; to develop protocols for rapid postoperative recovery (“fast track” in replacement surgery); to improve regenerative medicine strategies for degenerative diseases of hip and knee.

2. Author of 119 publications in international journals (Pubmed) and 19 other publications and book chapters. H-index Scopus: 34; Google Scholar: 44.

3. Member of Personalized Arthroplasty Society (PAS) – Education Committee and Corporate Development Committee since 2022.

4. Member of Education Committee (EduCom) of European Hip Society (EHS) since 2022.

5. Member of working groups of Network of Orthopaedic Registries of Europe (NORE, EFORT) since 2020.

6. Scientific Director – Fondazione Livio Sciutto Ricerca Biomedica in Ortopedia –ONLUS since 2018.

7. Editorial Board Member for International Journal of Orthopaedic since 2014.

8. Associate Editor for BMC Musculoskeletal Disorders since 2014.

9. Reviewer for Knee Surgery Sports Traumatology Arthroscopy Journal, BMC Musculoskeletal Disorders, Journal of Arthroplasty, Bone and Joint journal, International Orthopaedics, Hip International, International Journal Of Orthopaedic.

Loppini M, Di Maio M, Avigni R, Leone R, Inforzato A, Grappiolo G, Mantovani A, Bottazzi B. Long Pentraxin 3 as a New Biomarker for Diagnosis of Hip and Knee Periprosthetic Joint Infections. J Clin Med 2023 Jan 29;12(3):1055. doi: 10.3390/jcm12031055.
Loppini M, Gambaro FM, Chiappetta K, Grappiolo G, Bianchi AM, Corino VDA. Automatic Identification of Failure in Hip Replacement: An Artificial Intelligence Approach. Bioengineering (Basel) 2022 Jun 29;9(7):288. doi: 10.3390/bioengineering9070288.
Loppini M, Pisano A, Di Maio M, La Camera F, Casana M, Grappiolo G. (2021). Outcomes of patients with unexpected diagnosis of infection at total hip or total knee arthroplasty revisions. International orthopaedics, vol. 45, p. 2791-2796-2796, ISSN: 0341-2695, doi:10.1007/s00264-021-05137-8.
Grappiolo G, La Camera F, Della Rocca A, Mazziotta G, Santoro G, Loppini M. Total hip arthroplasty with a monoblock conical stem and subtrochanteric transverse shortening osteotomy in Crowe type IV dysplastic hips. Int Orthop 2019 Jan;43(1):77-83. doi: 10.1007/s00264-018-4122-5. Epub 2018 Sep 5.
Loppini M, Longo UG, Ragucci P, Trenti N, Balzarini L, Grappiolo G. Analysis of the Pelvic Functional Orientation in the Sagittal Plane: A Radiographic Study With EOS 2D/3D Technology. J Arthroplasty. 2017 Mar;32(3):1027-1032. doi: 10.1016/j.arth.2016.09.015. Epub 2016 Sep 28.