Home Members Martina Absinta

Martina Absinta

Associate Professor

Neurology

Associate Professor; Head of Experimental Neuropathology Lab

Education

2006 Medicine and Surgery (110/110 cum laude) / Vita-Salute San Raffaele University, Italy
2012 Neurology Residency (70/70 cum laude) / Vita-Salute San Raffaele University, Italy
2016 PhD in International Program of Molecular Medicine – Experimental Neurology / Vita-Salute San Raffaele University, Italy

Awards and Honors

2022 Young Physician-Scientist Award / The American Society for Clinical Investigation / US
2021 Rita-Levi Montalcini Prize / Italian MS Society (FISM/AISM) / Italy
2018 NIH Fellows Award for Research Excellence / NIH / US
2016 Award for 2016 Best Paper with IF between 10 and 20 / Italian Society of Neurology / Italy
2009 Award for best poster / Italian Society of Neurology / Italy

Single-cell genomics and multi-omics approaches to study neuroinflammatory and neurodegenerative disorders;
Human induced pluripotent stem cell-derived modelling of neuroinflammatory disorders;
Pathobiological understanding and radiological visualization of chronic inflammation in multiple sclerosis lesions and in the meningeal compartment;
Design of MRI-based clinical trials aimed at preventing or limiting chronic inflammation in multiple sclerosis.

Absinta M, Sati P, Schindler M, Leibovitch E, Ohayon J, Wu T, Meani A, Filippi M, Jacobson S, Cortese I, Reich DS. Poor outcome in MS lesions with persistent 7-tesla phase rim. J Clin Invest 2016
Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohajon J, Wu T, Cortese I, Reich DS.Chronic active multiple sclerosis lesions are associated with disability in vivo. JAMA Neurol. 2019
Absinta M, Maric D, Gharagozloo M, Garton T, Smith MD, Jin J, Fitzgerald KC, Song A, Liu P, Lin JP, Wu T, Johnson KR, McGavern DB, Schafer DP, Calabresi PA, Reich DS. A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis. Nature 2021
Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M.B cell depletion therapy does not resolve chronic active multiple sclerosis lesions. Lancet eBioMedicine 2023
[5] Fagiani F, Pedrini E, Taverna S, Brambilla, Murtaj V, Podini P, Ruffini F, Butti E, Braccia C, Andolfo A, Magliozzi R, Smirnova L, Kuhlmann T, Quattrini A, Calabresi PA, Reich DS, Martino G, Panina-Bordignon P, Absinta M. A glia-enriched stem-cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis. Cell Rep Med 2024