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Domenica Lorusso

Full Professor

Obstetrics and Gynecology

Full Professor

E-mail

domenica.lorusso@hunimed.eu

1995 Prof. Domenica Lorusso graduated with honours from the Faculty of Medicine and Surgery at the Università Cattolica del Sacro Cuore in Rome.
1999 she obtained her specialisation in Gynaecology and Obstetrics cum laude at the Catholic University of the Sacred Heart in Rome.
2003 she obtained a PhD in Gynaecology and Obstetrics at the University of Parma and in the same year she attended the Trials <Unit Clinic of the Department of Oncology of the “San Giovanni” Hospital in Bellinzona (CH) and the Breast Unit of the MD Anderson Cancer Center in Houston (USA).
2003-April 2007 he held the position of head of medical treatment of gynaecological neoplasms and clinical trials at the gynaecological oncology unit of the “Centro di Ricerca e Formazione ad Alta Tecnologia nelle Scienze Biomediche – Giovanni Paolo II” in Campobasso.
May 2007-October 2011 he held the position of head of medical treatment of gynaecological neoplasms and clinical trials at the gynaecological oncology unit of the “Fondazione Policlinico Universitario A Gemelli IRCCS” in Rome.
November 2011-December 2018 he served as head of medical treatment of gynaecological neoplasms and clinical trials at the gynaecological oncology unit of the “Fondazione IRCCS Istituto Nazionale Tumori” in Milan.
2019-2023 he headed the Clinical Research Development Unit at “Fondazione Policlinico Universitario A Gemelli IRCCS” in Rome.
2020-2023 he held the position of Associate Professor at ‘Università Cattolica del Sacro Cuore’ in Rome.
2024 she has held the position of Full Professor at Humanitas University in Rozzano and Director of the Operative Unit of Gynecological Oncology at Humanitas San Pio X.

Academic honours, awards and prices

2021 “Adele Leone memory” ACTO prize for Ovarian Cancer Treatment merit
ESGO 2017: Best oral presentation for “The Lyon study: Randomized phase 3 trial on the role of lynphadenectomy in Ovarian Cancer”.
GCIG 2016 Merit Awards for Endometrial Working Group Chair
INC Research 2016 Clinical Research Site Award

Prof. Lorusso has managed as principal investigator over 100 phase I, II, III and IV research studies dedicated to gynaecological oncology pathology.

She has been an active participant for over 25 years in the clinical research initiatives of cooperative groups dedicated to gynaecological cancers, including MITO, ENGOT, ESMO, ESGO and GCIG, and is still involved in the main initiatives for the development of new drugs in gynaecological oncology.

Prof. Lorusso is currently secretary of the MITO group (Multicenter Italian Trials in Ovarian Cancer and Gynecological Malignancies), is an active member of ENGOT (European Network of Gynaecological Oncological Trial groups) and of GCIG (Gynaecological Cancer Intergroup) where she was president of the working group on endometrial cancer and president of the nominations and extraordinary operations committee. She is currently a member of the Board of Directors of GCIG and a member of the Council of the European Society of Gynaecological Oncology (ESGO), as well as a member of the Scientific Committee for Gynaecological Tumours of ESMO (European Society of Medical Oncology).

An extender of international, European and national guidelines on the treatment of gynaecological malignancies, he currently coordinates the national working group on ovarian cancer treatment guidelines in the AIOM. Member of the editorial board of several peer-reviewed journals: his selection work helps to promote a high quality of literature in the field for readers and provides authors with a continuous effort to improve their research capabilities. Member of the scientific committee of the Italian Association for Cancer Research, member of the scientific committee of 3 patient advocacy groups: Abracadabra, Acto, Salute Donna.

Prof. Lorusso holds research funds for translational clinical activities, obtained from competitive public calls (AIRC and Ricerca Finalizzata Ministeriale).

Single-Agent Trabectedin Versus Physician’s Choice Chemotherapy in Patients With Recurrent Ovarian Cancer With BRCA-Mutated and/or BRCAness Phenotype: A Randomized Phase III Trial.Lorusso D, Raspagliesi F, Ronzulli D, Valabrega G, Colombo N, Pisano C, Cassani C, Tognon G, Tamberi S, Mangili G, Mammoliti S, De Giorgi U, Greco F, Mosconi AM, Breda E, Artioli G, Andreetta C, Casanova C, Ceccherini R, Frassoldati A, Salutari V, Giolitto S, Scambia G.J Clin Oncol. 2024 Feb 5:JCO2301225. doi: 10.1200/JCO.23.01225. Online ahead of print.PMID: 38315944
Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer.Moore KN, Angelergues A, Konecny GE, García Y, Banerjee S, Lorusso D, Lee JY, Moroney JW, Colombo N, Roszak A, Tromp J, Myers T, Lee JW, Beiner M, Cosgrove CM, Cibula D, Martin LP, Sabatier R, Buscema J, Estévez-García P, Coffman L, Nicum S, Duska LR, Pignata S, Gálvez F, Wang Y, Method M, Berkenblit A, Bello Roufai D, Van Gorp T; Gynecologic Oncology Group Partners and the European Network of Gynaecological Oncological Trial Groups.N Engl J Med. 2023 Dec 7;389(23):2162-2174. doi: 10.1056/NEJMoa2309169.PMID: 38055253
First-Line Pembrolizumab + Chemotherapy Versus Placebo + Chemotherapy for Persistent, Recurrent, or Metastatic Cervical Cancer: Final Overall Survival Results of KEYNOTE-826.Monk BJ, Colombo N, Tewari KS, Dubot C, Caceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Keefe SM, Lorusso D; KEYNOTE-826 Investigators.J Clin Oncol. 2023 Dec 20;41(36):5505-5511. doi: 10.1200/JCO.23.00914. Epub 2023 Nov 1.PMID: 37910822
Newly diagnosed and relapsed epithelial ovarian cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.González-Martín A, Harter P, Leary A, Lorusso D, Miller RE, Pothuri B, Ray-Coquard I, Tan DSP, Bellet E, Oaknin A, Ledermann JA; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org.Ann Oncol. 2023 Oct;34(10):833-848. doi: 10.1016/j.annonc.2023.07.011. Epub 2023 Aug 17.PMID: 37597580
Lenvatinib Plus Pembrolizumab in Previously Treated Advanced Endometrial Cancer: Updated Efficacy and Safety From the Randomized Phase III Study 309/KEYNOTE-775.Makker V, Colombo N, Casado Herráez A, Monk BJ, Mackay H, Santin AD, Miller DS, Moore RG, Baron-Hay S, Ray-Coquard I, Ushijima K, Yonemori K, Kim YM, Guerra Alia EM, Sanli UA, Bird S, Orlowski R, McKenzie J, Okpara C, Barresi G, Lorusso D.J Clin Oncol. 2023 Jun 1;41(16):2904-2910. doi: 10.1200/JCO.22.02152. Epub 2023 Apr 14.PMID: 37058687