Home Members Antonio Costanzo

Antonio Costanzo

Full Professor

Dermatology

Full Professor of Dermatology, Director of Postgraduate School of Dermatology, Director of the Skin Pathology Laboratory, Humanitas University, Board Member of the European Dermatology Forum

E-mail

Antonio.costanzo@hunimed.eu
Telefono

+390282247705
Sito

www.humanitas-research.org/groups/antonio-costanzo-group/

1994 he graduated with his MD degree in Medicine and Surgery from the University of Rome, La Sapienza
1999 he went on to complete post-graduate study and received a speciality degree in Internal Medicine
2006 Dermatology speciality degree.

His clinical research is focused on the characterization of the activity of biologics in psoriasis and psoriatic arthritis. This research is strictly linked to basic research activity on the pathogenesis of psoriasis and on the use of pharmacogenetic approach to predict the efficacy and safety of biologics in psoriasis.

In the past, Professor Costanzo has collaborated to the characterization of basic mechanisms of TNF inflammatory signalling in epithelial cells and NFkappaB regulation by different stimuli. More recently his research group has collaborated to the discovery of IL-21 as critical mediator of keratinocyte proliferation in psoriasis. Professor Costanzo has authored or co-authored more than 120 publications in internationally peer-reviewed journals.

In our group we study the molecular mechanism at the basis of immune-mediated cutaneous disease as Psoriasis, a chronic inflammatory, hyperproliferative skin disease, using the approach of epigenetic analysis (ChIP seq) and gene regulation technics to map key genes responsible of the onset of the skin hyperproliferation, and to highlight the genes that respond to the different drug therapy. We are interested in Pharmacogenetic, to correlate the response of biological drugs to the different haplotypes. INNODERM project focus on the development of an Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy.

IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis.Galluzzo M1, Boca AN, Botti E, Potenza C, Malara G, Malagoli P, Vesa S, Chimenti S, Buzoianu AD, Talamonti M, Costanzo A., Dermatology. 2016;232(2):230-6. doi: 10.1159/000441719. Epub 2015 Dec 18., https://www.karger.com/Article/FullText/441719
Use of biological drugs in patients with psoriasis and psoriatic arthritis in Italy: Results from the PSONG survey. Potenza MC, Peris K, Berardesca E, Bianchi L, Richetta A, Bernardini N, De Simone C, Teoli M, Zangrilli A, D’epiro S, Orsini D, Narcisi A, Chimenti S, Costanzo A., Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12565. Epub 2017 Dec 7., https://onlinelibrary.wiley.com/doi/epdf/10.1111/dth.12565
The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis., Lande R, Botti E, Jandus C, Dojcinovic D, Fanelli G, Conrad C, Chamilos G, Feldmeyer L, Marinari B, Chon S, Vence L, Riccieri V, Guillaume P, Navarini AA, Romero P, Costanzo A, Piccolella E, Gilliet M, Frasca L., Nat Commun. 2014 Dec 3;5:5621. doi: 10.1038/ncomms6621., https://www.nature.com/articles/ncomms6621
Disease-related and drug-induced skin manifestations in inflammatory bowel disease., Hindryckx P, Novak G, Costanzo A, Danese S., Expert Rev Gastroenterol Hepatol. 2017 Mar;11(3):203-214. doi: 10.1080/17474124.2017.1283985. Epub 2017 Feb , https://www.tandfonline.com/doi/abs/10.1080/17474124.2017.1283985?journalCode=ierh20
Listening in to skin disease Optoacoustic mesoscopy promises to be a fast and reliable non-invasive method for the diagnosis of psoriasis. Narcisi A, Favaro R. Costanzo A., Nature Biomedical Engineering 1, 0076 (2017) | DOI: 10.1038/s41551-017-0076, https://www.nature.com/articles/s41551-017-0076.pdf?origin=ppub