Education
- 2003 PhD in Endocrinology, University of Milan
- 1997 Post-Graduate degree in Endocrinology, University of Milan
- 1991 MD degree, University of Milan
Academic background
- 2015-2022 Associate Professor of Endocrinology, Department of Biomedical Sciences, Humanitas University
- 2005-2015 Assistant Professor, University of Milan, Italy
Teaching appointments
System Diseases 3 Course Coordinator at Humanitas University
Other institutional appointments
- Director of Postgraduate Residency Program for Endocrinology at Humanitas University
- Member of The Quality Presidium at Humanitas University
- Director of Endocrinology, Diabetology and Andrology Units at IRCCS Humanitas Research Hospital
- Director of the Endocrinolgy, Diabetology and Andrology Unit and the Laboratory of Cellular and Molecular Endocrinology at IRCCS Istituto Clinico Humanitas
- Coordinator (with Prof. Zerbi) of the Neuroendocrine multidisciplinary tumor board certified as Center of Excellence by the European NeuroEndocrine Tumors Society (ENETS)
- Humanitas Research Hospital Health Care Representative at ERN EURACAN (European Reference Network on adult cancer – solid tumors)
Prof. Lania published 198 peer-reviewed papers (Google Scholar H-Index 47; Scopus H-Index 38, cit tot 4604)
Prof. Lania has a long standing expertise in the field of intra-cellular signaling in endocrine tumors. In particular, in the past ten years, he contributed to analyze the role of PKA regulatory subunits in the pathogenesis and control of cell proliferation of endocrine tumors. Moreover, he contributed to define the role of SSTR5 domains involved in the intracellular trafficking of this receptor in human pituitary cells and to analyze the impact of DR2R and SSTR2&5 polymorphic variants on both the clinical outcome and response to medical treatment in patients with pituitary tumors.
Recently, he contributed to identify the role of cytoskeleton protein FLNA in mediating both intracellular signaling and membrane targeting of somatostatin type 2 receptor and D2R in pituitary and pancreatic neuroendocrine tumors. Finally, he contributed to explore the intracellular mechanisms possibly involved in mediating the interplay between drugs commonly used in the treatment of neuroendocrine tumors.
- Mirani M, Favacchio G, Carrone F, Betella N, Biamonte E, Morenghi E, Mazziotti G, Lania AG. Impact of Comorbidities and Glycemia at Admission and Dipeptidyl Peptidase 4 Inhibitors in Patients With Type 2 Diabetes With COVID-19: A Case Series From an Academic Hospital in Lombardy, Italy. Diabetes Care. 2020 Dec;43(12):3042-3049. doi: 10.2337/dc20-1340. Epub 2020 Oct 6. PMID: 33023989.
- Lania A, Sandri MT, Cellini M, Mirani M, Lavezzi E, Mazziotti G. Thyrotoxicosis in patients with COVID-19: the THYRCOV study. Eur J Endocrinol. 2020 Oct;183(4):381-387. doi: 10.1530/EJE-20-0335. PMID: 32698147.
- Vitali E, Boemi I, Tarantola G, Piccini S, Zerbi A, Veronesi G, Baldelli R, Mazziotti G, Smiroldo V, Lavezzi E, Spada A, Mantovani G, Lania AG. Metforminand Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment.Cancers (Basel). 2020 Aug 2;12(8):2143. doi: 10.3390/cancers12082143. PMID: 32748870; PMCID: PMC7464161.
- Vitali E, Cambiaghi V, Zerbi A, Carnaghi C, Colombo P, Peverelli E, Spada A, Mantovani G, Lania AG. Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours. Endocr Relat Cancer. 2016 Mar;23(3):181-90. doi: 10.1530/ERC-15-0358. Epub 2016 Jan 5. PMID: 26733502.
- Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A. Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Cancer Res. 2004 Dec 15;64(24):9193-8. doi: 10.1158/0008-5472.CAN-04-1847. PMID: 15604292.
