Home Members Antonietta Franco

Antonietta Franco

Assistant Professor

Physiology

Assistant professor

E-mail

antonietta.franco@hunimed.eu

Education

March 2024 – Present Assistant Professor, Humanitas University, Milan (IT)
2019 – 2023 Research instructor, Washington University School of Medicine, St. Louis, MO (US)
2019 – Present Technical consultant Mitochondria in Motion St. Louis, MO (USA)
2016 – 2019 Postdoc Research Associate, Pharmacogenomics/IM Department, Washington University, St. Louis, MO, (USA)
2013 – 2016 PhD, University of Naples Federico II, Naples (IT)
2013 Summer Research Student, GSI Helmholtzzentrum für Schwerionenforschung, Frankfurt (DE)
2011 International exchange program, Imperial College London; London (UK)

Academic background

2016: PhD in Clinical Pathology and Physiology, University of Naples, Federico II (Italy)
2012: Master’s degree in Med. Biotechnology, University of Naples, Federico II (Italy)
2010: Bachelor’s degree in Biotechnology, University of Naples, Federico II (Italy)

Academic honors, awards and prices

2011 International exchange program with universities and research institutes for foreigners to short-term mobility of teachers, Scholars and Researchers.
2014 Travel-Grant FCVB (Frontiers in Cardiovascular Biology), ESC Congress (European society Cardiology), 4-6 July 2014 Barcelona, Spain.
2014 Travel-Grant S.I.I.A. Societa’ Italiana di Ipertensione Arteriosa (S.I.I.A.), 9-10 October 2014 Bologna, Italy
2014 Best Poster “Heart Session” Societa’ Italiana Ipertensione Arteriosa (SIIA). Title: “Ionizing radiation modifies in time dependent manner the subcellular localization of GRK2 in cardiomyocytes”
2016 “Postdoctoral Fellowship Societa Italiana Ipertensione Arteriosa (SIIA) “Cesare Bartorelli”
2017 Washington University School of Medicine (St. Louis, MO-USA) Mc-Donnell Center for Cellular and Molecular Neurobiology Postdoctoral

Fellowship

2018 Finalist O’Leary Competition Excellence in Neuroscience, Washington University School of Medicine St. Louis, MO, USA.

The principal aim of Dr. Franco’s research for the near future is to understand the molecular mitochondria mechanism and clinical relevance in mitochondrial fusion defects linked to cardiac abnormalities and neurodegenerative diseases. Eight years ago, when she first committed to mitochondrial research, she started by studying hereditary mitochondrial fusion dysfunctions in the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). Moving forward, she plans to continue to focus on hereditary mitochondrial fusion defects in cardiac abnormalities
The long-term goal of this project will be finding ways to therapeutically approach treating mitochondrial fusion defects in heart failure and neurological diseases. This research will have high relevance since she will analyze the human variants that induce hereditary disease.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature. 2016 Dec 1;540 (7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24. PMID: 27775718
Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017 Dec 5;26(6):872-883.e5. doi: 10.1016/j.cmet.2017.09.023. Epub 2017 Oct 26.PMID:29107503
Rocha AG(*), Franco A(*), Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW2nd. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.Science. 2018 Apr 20;360(6386):336- 341doi:10.1126/science.aao1785. PMID:29674596
Franco A., Dang X., Walton E., Ho J., Zablocka B., Ly C., Miller T., Baloh R., Shy M., Yoo A.,
Dorn II GW. Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A Elife. 2020 Oct 19;9:e61119. doi: 10.7554/eLife.61119. Online ahead of print. PMID: 33074106
Franco A., Li J., Kelly D., Hershberger R., Marian A., Lewis R., Song M., Dang X., D. Schmidt A., Mathyer M. , Edwards R.J. de Guzman Strong C., Dorn II G. A human mitofusin 2 mutation cam cause mitophagic cardiomyopathy. (ElifeNov 1, 2023 https://doi.org/10.7554/eLife.84235)

(*) These authors contributed equally to this work