Home Members Gabriele Todisco

Gabriele Todisco

Assistant Professor

Hematology

Assistant Professor

E-mail

gabriele.todisco@hunimed.eu
Sito

www.humanitas.it/medici/gabriele-todisco

Education

2015-2019 Resident in Hematology at Pavia University, Italy
2010-2015 Resident in Internal Medicine at Vita-Salute San Raffaele University, Milan, Italy
2009 Medical Degree at Vita-Salute San Raffaele University, Milan, Italy

Academic background

From June 2021 to February 2022 Assistant Professor in Hematology at Pavia University, Italy
From November 2019 to May 2021 Post-doctoral researcher at Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
From December 2014 to June 2015 Post-Doctoral Fellow at Leukemia Department, MD Anderson Cancer Center, Houston (TX)

He has been working on translational research projects in myeloid neoplasms since 2018 focusing on incorporating detailed molecular information from DNAseq and RNAseq into clinical practice. His research is aiming to improve classification and treatment of myeloid neoplasms by exploring germline and acquired mechanisms driving myeloid neoplasms development and disease progression. He is member of Italian Hematology Society and Nordic MDS Research Group.

Moura PL, Mortera-Blanco T, Hofman IJ, Todisco G, et al. Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts. Cancer Res. 2024 Jan 16;84(2):211-225.
Todisco G, Creignou M, Bernard E, Hellström-Lindberg E, et al. Integrated genomic and transcriptomic analysis improves disease classification and risk stratification of MDS with ring sideroblasts. Clin Cancer Res. 2023 Oct 13;29(20):4256-4267
Cieśla M, Ngoc PCT, Muthukumar S, Todisco G, et al. m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis. Mol Cell. 2023 Apr 6;83(7):1165-1179.e11
Nicola Guzzi, Sowndarya Muthukumar, Maciej Cieśla, Gabriele Todisco, et al. Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome. Nat Cell Biol. 2022 Mar;24(3):299-306.
Ellen M. Beauchamp, Matthew Leventhal, Elsa Bernard, Emma R Hoppe, Gabriele Todisco, et al. ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discov. 2021 Sep;2(5):500-517.