Piergiuseppe Colombo

Prof. Colombo since the first years after his specialization has been working on histological, immunophenotypic and genomic prognostic markers related to the biological aggressiveness of urological neoplasms such as prostate cancer and bladder cancer and on the diagnosis and genomics of gastrointestinal stromal tumor (GIST). Over the years he focused on the research of predictive markers of recurrence in sarcomas of the retroperitoneum, on the pre-clinical analysis of the inflammatory tumor microenvironment and on the relationships between microscopic and radiological features for the evaluation of response to therapy in soft tissue sarcomas. In recent years he developed a line of research for the histological characterization of rare forms of kidney cancer with poor prognosis. In these areas of study he had collaborations with research groups both at national and international level.

Currently, he is focusing on prognostic and predictive markers in bladder carcinoma, histological markers of aggressiveness in prostate and testicular tumor and the characterization of new emerging entities in the spectrum of kidney tumors. Prof. Colombo is Co-editor in 5° Edition of WHO Classification of Tumors of Urinary System and Male genital organs, “Blue Book”, IARC, 2022.

1. Rodriguez Pena MDC, Canete-Portillo S, Amin A, Aron M, Colombo P, Cox R, Baydar DE, Gallegos I, Khani F, Michalova K, Lucianò R, Miyamoto H, Osunkoya AO, Raspollini MR, Sánchez DF, Scarfo F, So JS, Zynger DL, Wei S, Netto GJ, Magi-Galluzzi C. Testicular Germ-Cell Tumors with Spermatic Cord Involvement: A Retrospective International Multi-Institutional Experience. MODERN PATHOLOGY. 2021 Sep 9. doi: 10.1038/s41379-021-00912-9. PMID: 34504308.

2. Gennaro N, Reijers S, Bruining A, Messiou C, Haas R, Colombo P, Bodalal Z, Beets-Tan R, van Houdt W, van der Graaf WTA (2021). Imaging Response Evaluation after Neoadjuvant Treatment in Soft Tissue Sarcomas: Where Do We Stand?CRIT REV ONCOL HEMATOL. Mar 20:103309. doi: 10.1016/j.critrevonc.2021.103309

3. Oresta B, Pozzi C, Braga D, Hurle R, Lazzeri M, Colombo P, Frego N, Erreni M, Faccani C, Elefante G, Barcella M, Guazzoni G, Rescigno M (2021). Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer. SCIENCE TRANSLATIONAL MEDICINE, doi: 10.1126/scitranslmed.aba6110. PMID: 33408185.

4. Sirohi D, Smith SC, Ohe C, Colombo P, Divatia M, Dragoescu E, Rao P, Hirsch MS, Chen YB, Mehra R, Amin MB. (2017). Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma. HUMAN PATHOLOGY, DOI: 10.1016/j.humpath.2017.07.006. ISSN: 0046-8177

5. Colombo P, Smith SC, Massa S, Renne SL, Brambilla S, Peschechera R, Graziotti P, Roncalli M, Amin MB. (2015). Unclassified Renal Cell Carcinoma With Medullary Phenotype Versus Renal Medullary Carcinoma: Lessons From Diagnosis in an Italian Man Found to Harbor Sickle Cell Trait. UROLOGY CASE REPORTS, DOI: 10.1016/j.humpath.2017.07.006. ISSN: 2214-4420
6. Colombo P, Patriarca C, Alfano RM, Cassani B, Ceva Grimaldi G, Roncalli M, Bosari S, Coggi G, Campo B, Gould VE. (2001). Molecular disorders in transitional vs. peripheral zone prostate adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER, doi: 10.1002/ijc.1485. ISSN: 0020-7136.